by Philippe Jeanteur, Cytoplasmic Fate Of Messenger Rna Books available in PDF, EPUB, Mobi Format. Download Cytoplasmic Fate Of Messenger Rna book, Among all cellular RNA species of the three main types, ribosomal RNA, transfer RNA or messenger RNA, be they from prokaryotic or eukaryotic organisms, the prokaryotic mRNA is unique in that it has no precursor and is synthesized in the same mature form as it is translated into proteins. In fact, ribosomes join the nascent mRNA chain and engage in protein synthesis long before its transcription is complete. Provisions are even made for slowing down the ribo somes at some sites to prevent them from catching up with the RNA-polymerase. Of course, such a situation is only possible in the prokaryotic world where there is no such thing as a nuclear mem brane physically secluding the transcription process from the cy toplasm where translation is restricted. Quite in the opposite extreme, the eukaryotic pre-messenger RNA has to suffer many and sometimes drastic steps of maturation (capping, polyadenylation, splicing, edition) before the decision is made to export it to the cytoplasm. That is where it enters the scope of this book. Once in the cytoplasm, many options are still open to it: its entrance into polysomes may be delayed (as it is in unfertilized eggs) or merely prohibited (ferritin mRNA in iron-starved cells), directed to specific locations within the cytoplasm or be more or less rapidly degraded. During gametogenesis and early development, translational control is probably the most significant level of gene expression.
by Philippe Jeanteur, Cytoplasmic Fate Of Messenger Rna Books available in PDF, EPUB, Mobi Format. Download Cytoplasmic Fate Of Messenger Rna book, This book summarizes the current knowledge on a cascade of gene regulation levels which operate in the cytoplasm of eukaryotic cells and which has until recently been poorly understood. While transcriptional control of eukaryotic genes has been extensively researched and the understanding of this process has reached very sophisticated levels, post- transcriptional control has received much less attention. As the contributions in this book demonstrate, not only is post-transcriptional control in eukaryotes better understood, it is now thought to be a major player in gene expression control in a number of key processes, i.e. control of cell proliferation, gametogenesis and early development or cellular homeostasis.
by Johanna Shumway Carroll, Post Transcriptional Regulation Of Gene Expression By The Dexd H Box Protein Dhh1 Books available in PDF, EPUB, Mobi Format. Download Post Transcriptional Regulation Of Gene Expression By The Dexd H Box Protein Dhh1 book, By repressing translation and promoting mRNA decay, cells are able to modulate gene expression and respond swiftly to changing environmental signals and developmental cues. Although translation, storage and degradation of mRNAs are key steps in the post-transcriptional control of gene expression, how mRNAs transit between these processes remains poorly understood. During my thesis I functionally characterized the DExD/H box ATPase Dhh1, a critical regulator of the cytoplasmic fate of mRNAs. Using mRNA tethering experiments in yeast, I showed that Dhh1 is sufficient to move an mRNA from an active state to translational repression. In actively dividing cells, translational repression is followed by mRNA decay, however, deleting components of the 5' to 3' decay pathway uncoupled these processes. Interestingly, Dhh1's ability to inactivate an mRNA coincided with its ability to move mRNAs into cytoplasmic processing bodies (P bodies). I also examined the role of ATP hydrolysis in Dhh1's ability to repress translation and activate mRNA decay. While Dhh1's ATPase activity is not essential for translational inhibition and mRNA decay in dhh1[Delta] cells, I found that ATP hydrolysis regulates P body dynamics and the release of Dhh1 from these RNA-protein granules. Surprisingly, I found that the presence of a wild-type copy of Dhh1 rescues the abnormal P-body localization of a Dhh1 ATPase-mutant. Additionally, the Dhh1 ATPase mutant no longer reduces mRNA and protein levels when tethered to an mRNA in the presence of a wild-type copy of Dhh1. My results place Dhh1 at the interface of translation and decay controlling whether an mRNA is translated, stored or decayed.
by Eckhard Jankowsky, Rna Helicases Books available in PDF, EPUB, Mobi Format. Download Rna Helicases book, This work integrates the current knowledge about RNA helicases from diverse fields ranging from cell and developmental biology to mechanistic enzymology and structural biology into one useful resource.
by Tzvi Tzfira, Nuclear Import And Export In Plants And Animals Books available in PDF, EPUB, Mobi Format. Download Nuclear Import And Export In Plants And Animals book, Nuclear Import and Export in Plants and Animals provides insight into the remarkable mechanisms of nuclear import and export. This book covers a range of topics from the nuclear pore structure, to nuclear import and export of macromolecules in plant and animal cells. In addition, the book covers the special cases of nuclear import of Agrobacterium T-DNA during plant genetic transformation, nuclear import and export of animal viruses, and nuclear intake of foreign DNA. A chapter on research methods to study nuclear transport concludes the book.
Author: Proceedings of the National Academy of Sciences Publisher: National Academies Press ISBN: 0309074258 Size: 66.59 MB Format: PDF Category : Biological transport, Active Languages : en Pages : 116 View: 6762
by Proceedings of the National Academy of Sciences, Molecular Kinesis In Cellular Function And Plasticity Books available in PDF, EPUB, Mobi Format. Download Molecular Kinesis In Cellular Function And Plasticity book,
by Thomas D. Pollard, Cell Biology E Book Books available in PDF, EPUB, Mobi Format. Download Cell Biology E Book book, The much-anticipated 3rd edition of Cell Biology delivers comprehensive, clearly written, and richly illustrated content to today’s students, all in a user-friendly format. Relevant to both research and clinical practice, this rich resource covers key principles of cellular function and uses them to explain how molecular defects lead to cellular dysfunction and cause human disease. Concise text and visually amazing graphics simplify complex information and help readers make the most of their study time. Clearly written format incorporates rich illustrations, diagrams, and charts. Uses real examples to illustrate key cell biology concepts. Includes beneficial cell physiology coverage. Clinically oriented text relates cell biology to pathophysiology and medicine. Takes a mechanistic approach to molecular processes. Major new didactic chapter flow leads with the latest on genome organization, gene expression and RNA processing. Boasts exciting new content including the evolutionary origin of eukaryotes, super resolution fluorescence microscopy, cryo-electron microscopy, gene editing by CRISPR/Cas9, contributions of high throughput DNA sequencing to understand genome organization and gene expression, microRNAs, IncRNAs, membrane-shaping proteins, organelle-organelle contact sites, microbiota, autophagy, ERAD, motor protein mechanisms, stem cells, and cell cycle regulation. Features specially expanded coverage of genome sequencing and regulation, endocytosis, cancer genomics, the cytoskeleton, DNA damage response, necroptosis, and RNA processing. Includes hundreds of new and updated diagrams and micrographs, plus fifty new protein and RNA structures to explain molecular mechanisms in unprecedented detail.
by Georg Löffler, Biochemie Und Pathobiochemie Books available in PDF, EPUB, Mobi Format. Download Biochemie Und Pathobiochemie book, "Der Löffler/Petrides ist das, was sich jeder Student wünscht: Ein topaktuelles Lehrbuch, das zu jeder erdenklichen Frage eine Antwort parat hat." (Studentenzitat) Neu: Das Standardwerk der Biochemie wurde von 22 renommierten Experten in jeder Hinsicht runderneuert: - Die enge Verknüpfung von theoretischen Inhalten und klinischer Praxis wird noch überzeugender herausgestellt. Die großzügige Ausstattung mit aussagekräftigen Abbildungen erleichtern den Zugang zu komplizierten biochemischen Zusammenhängen. Konsequent klar strukturierte und gewichtete Inhalte steuern den Lernprozess, unterstützt durch einprägsame Merksätze, aktuelle Infoboxen, zusammenfassende Kernaussagen, Schlüsselbegriffe und ein umfangreiches Register. Unser Angebot: Aktualität, Ausgewogenheit und Zuverlässigkeit.