Proteomics Of The Nervous System

Proteomics of the Nervous System PDF
Author: Hans Gerd Nothwang
Publisher: Wiley-Blackwell
ISBN: 9783527317165
Size: 68.76 MB
Format: PDF
Category : Medical
Languages : en
Pages : 332
View: 2150

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Proteomics Of The Nervous System

by Hans Gerd Nothwang, Proteomics Of The Nervous System Books available in PDF, EPUB, Mobi Format. Download Proteomics Of The Nervous System book, Covering applications in both biomedical and basic research, this is the first book to combine the cutting-edge technology of proteomics with the highly important field of neuroscience. This ready reference provides the theoretical foundations, protocols for a number of key proteomic techniques, and cases studies of the application of proteomics to brain and neural research.



Neuroproteomics

Neuroproteomics PDF
Author: Andrew K. Ottens
Publisher: Humana Press
ISBN: 9781617797545
Size: 28.44 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 321
View: 5782

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Neuroproteomics

by Andrew K. Ottens, Neuroproteomics Books available in PDF, EPUB, Mobi Format. Download Neuroproteomics book, Neuroproteomics: Methods and Protocols presents experimental details for applying proteomics to the study of the central nervous system (CNS) and its dysfunction through trauma and disease. The target audience includes clinical or basic scientists who look to apply proteomics to the neurosciences. Often researchers hear of proteomics without an adequate explanation of the methodology and inherent limitations. This volume conveys where proteomic methodology is in its application to CNS research and what results can be expected. We also address clinical translation of neuroproteomics, specifically in the area of biomarker research. The inception of neuroproteomics capitalized on rapid progress in large-molecule mass spectrometry over the last decade. Two seminal advances have spurred research – development of reliable polypeptide ionization processes and bioinformatics to rapidly process tandem mass spectra for peptide identification and quantification. What has followed is the exponential application of mass spectrometry to proteome characteri- tion across biological and biomedical disciplines. Arguably, the most elaborate proteomic implementation is in studying the CNS, the most enigmatic and complex animal system. Neuroscience is characterized by grandiose questions – what is consciousness, how does thought or memory work. Neuroproteomics researchers, however, have pri- rily involved themselves dysfunction, based on a pressing need (and invariably funding), in answering questions on CNS dysfunction, based on a pressing need (and invariably funding), and because such questions hold more accessible answers. Dysfunction is readily contrasted against normal function and presumably produces a lasting differential protein signature.



Proteomics And The Premortem Diagnosis Of Central Nervous System Disease

Proteomics and the Premortem Diagnosis of Central Nervous System Disease PDF
Author: Leila H. Choe
Publisher:
ISBN:
Size: 38.56 MB
Format: PDF, ePub, Docs
Category : Chemical engineering
Languages : en
Pages : 4
View: 6176

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Proteomics And The Premortem Diagnosis Of Central Nervous System Disease

by Leila H. Choe, Proteomics And The Premortem Diagnosis Of Central Nervous System Disease Books available in PDF, EPUB, Mobi Format. Download Proteomics And The Premortem Diagnosis Of Central Nervous System Disease book,



Lymphoma And Leukemia Of The Nervous System

Lymphoma and Leukemia of the Nervous System PDF
Author: Tracy Batchelor
Publisher: Springer Science & Business Media
ISBN: 9781441976680
Size: 34.16 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 415
View: 7050

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Lymphoma And Leukemia Of The Nervous System

by Tracy Batchelor, Lymphoma And Leukemia Of The Nervous System Books available in PDF, EPUB, Mobi Format. Download Lymphoma And Leukemia Of The Nervous System book, This is the second edition of a book called "Lymphoma of the Nervous System," which was published by Butterworth-Heinemann (B-H) in 2004. Lymphoma and Leukemia of the Nervous System is a comprehensive review of this challenging group of diseases and should be useful for the practicing neurologist, hematologist, oncologist and for any practitioner involved in the management of these patients.



Biomedical Applications Of Proteomics

Biomedical Applications of Proteomics PDF
Author: Jean-Charles Sanchez
Publisher: John Wiley & Sons
ISBN: 3527605835
Size: 21.32 MB
Format: PDF, Mobi
Category : Science
Languages : en
Pages : 452
View: 3051

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Biomedical Applications Of Proteomics

by Jean-Charles Sanchez, Biomedical Applications Of Proteomics Books available in PDF, EPUB, Mobi Format. Download Biomedical Applications Of Proteomics book, In this first book to provide an overview of applications of proteomics in the discovery of new diagnostic, prognostic and therapeutic targets, a team of international specialists from research institutions, hospitals and companies contribute with their specific expertise. They cover a wide range of example applications for the most important diseases, such as heart and cardiovascular disorders, cancer, pharmatoxicology, infectious diseases and diseases of the nervous system. Denis Hochstrasser is an eminent scientist in the field of bioinformatics and proteomics and one of the founders of the Swiss Prot Databank as well as of the Swiss biotech company Genebio.



Proteomics And Genetic Studies Of Dystroglycan Function In The Nervous System

Proteomics and Genetic Studies of Dystroglycan Function in the Nervous System PDF
Author: Yougen Zhan
Publisher:
ISBN:
Size: 14.99 MB
Format: PDF, Docs
Category :
Languages : en
Pages : 396
View: 3583

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Proteomics And Genetic Studies Of Dystroglycan Function In The Nervous System

by Yougen Zhan, Proteomics And Genetic Studies Of Dystroglycan Function In The Nervous System Books available in PDF, EPUB, Mobi Format. Download Proteomics And Genetic Studies Of Dystroglycan Function In The Nervous System book, "Muscular dystrophies are a group of diseases that are often caused by loss-of-function mutations affecting the dystrophin glycoprotein complex (DGC). The common feature of the diseases is muscle degeneration, which is often associated with mental retardation and various retinal defects, including ones of synaptic transmission. However, the mechanisms of the disease remain largely unknown, especially those in the central nervous system. I have focused on dystroglycan (DG), the transmembrane protein in the DGC that links the cytoskeleton to the extracellular matrix and is essential for muscle survival and brain development. I have used proteomics and Drosophila genetics to study DG function in the brain and retina." --



Applications Of Biotechnology In Neurology

Applications of Biotechnology in Neurology PDF
Author: Kewal K. Jain
Publisher: Springer Science & Business Media
ISBN: 162703272X
Size: 57.25 MB
Format: PDF, Mobi
Category : Medical
Languages : en
Pages : 638
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Applications Of Biotechnology In Neurology

by Kewal K. Jain, Applications Of Biotechnology In Neurology Books available in PDF, EPUB, Mobi Format. Download Applications Of Biotechnology In Neurology book, Culling together excerpts from a wide range of writings by Dr. Kewal K. Jain on biotechnology topics as they relate to disorders of the nervous system, Applications of Biotechnology in Neurology covers a variety of applications for those working in life sciences and the pharmaceutical sciences, particularly those developing diagnostics and therapeutics for the nervous system. This detailed volume delves into areas such as neurobiotechnology, like neurogenomics and neuroproteomics, molecular diagnostics, various methods of improving systemic administration of drugs for targeted delivery to the nervous system, including the use of nanobiotechnology, biotechnology-based strategies and products for neuroprotection, as well as chapters on neurosurgery and personalized neurology. Thorough, cutting-edge, and thoughtfully organized, Applications of Biotechnology in Neurology serves as an ideal guide, supplemented by 75 tables and 16 figures as well as numerous references from recent literature on this topic, which are appended to each chapter.



Neuroproteomics

Neuroproteomics PDF
Author: Oscar Alzate
Publisher: CRC Press
ISBN: 9781420076264
Size: 13.59 MB
Format: PDF, ePub
Category : Science
Languages : en
Pages : 354
View: 5395

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Neuroproteomics

by Oscar Alzate, Neuroproteomics Books available in PDF, EPUB, Mobi Format. Download Neuroproteomics book, In this, the post-genomic age, our knowledge of biological systems continues to expand and progress. As the research becomes more focused, so too does the data. Genomic research progresses to proteomics and brings us to a deeper understanding of the behavior and function of protein clusters. And now proteomics gives way to neuroproteomics as we begin to unravel the complex mysteries of neurological diseases that less than a generation ago seemed opaque to our inquiries, if not altogether intractable. Edited by Dr. Oscar Alzate, Neuroproteomics is the newest volume in the CRC Press Frontiers of Neuroscience Series. With an extensive background in mathematics and physics, Dr. Alzate exemplifies the newest generation of biological systems researchers. He organizes research and data contributed from all across the world to present an overview of neuroproteomics that is practical and progressive. Bolstered by each new discovery, researchers employing multiple methods of inquiry gain a deeper understanding of the key biological problems related to brain function, brain structure, and the complexity of the nervous system. This in turn is leading to new understanding about diseases of neurological deficit such as Parkinson’s and Alzheimer’s. Approaches discussed in the book include mass spectrometry, electrophoresis, chromatography, surface plasmon resonance, protein arrays, immunoblotting, computational proteomics, and molecular imaging. Writing about their own work, leading researchers detail the principles, approaches, and difficulties of the various techniques, demonstrating the questions that neuroproteomics can answer and those it raises. New challenges wait, not the least of which is the identification of potential methods to regulate the structures and functions of key protein interaction networks. Ultimately, those building on the foundation presented here will advance our understanding of the brain and show us ways to abate the suffering caused by neurological and mental diseases.



Methods In Animal Proteomics

Methods in Animal Proteomics PDF
Author: Philip Whitfield
Publisher: John Wiley & Sons
ISBN: 0470960647
Size: 36.61 MB
Format: PDF, ePub, Docs
Category : Science
Languages : en
Pages : 452
View: 4237

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Methods In Animal Proteomics

by Philip Whitfield, Methods In Animal Proteomics Books available in PDF, EPUB, Mobi Format. Download Methods In Animal Proteomics book, The study of proteomics provides researchers with a better understanding of disease and physiological processes in animals. Methods in Animal Proteomics will provide animal scientists and veterinarians currently researching these topics in domestic animals a firm foundation in the basics of proteomics methodology, while also reviewing important advances that will be of interest to established researchers in the field. Chapters will provide practical information on a range of topics including protein identification and separation, bioinformatics, and applications to disease and reproduction research. This text will be written by leading international proteomics experts and essential for researchers in the fields of animal biology and veterinary medicine.



Combined Modality Therapy Of Central Nervous System Tumors

Combined Modality Therapy of Central Nervous System Tumors PDF
Author: Zbigniew Petrovich
Publisher: Springer Science & Business Media
ISBN: 3642564119
Size: 64.24 MB
Format: PDF
Category : Medical
Languages : en
Pages : 640
View: 2855

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Combined Modality Therapy Of Central Nervous System Tumors

by Zbigniew Petrovich, Combined Modality Therapy Of Central Nervous System Tumors Books available in PDF, EPUB, Mobi Format. Download Combined Modality Therapy Of Central Nervous System Tumors book, The American Cancer Society anticipates that 16,500 patients will be diagnosed with primary malignant tumors of the central nervous system in 2000, with about 200,000 individuals presenting with brain metastases. The advances in the treatment of solid tumors have contributed significantly to the major increase in metastatic cancers to the brain. Of the primary malignant tumors of the brain, more than 50% are high-grade gliomas; the incidence has been increasing among older patients over the past decade. Major developments in new technologies in the treatment of primary brain tumors as well as metastatic disease are covered in depth. Even though management is difficult, advances are being made. This book is a concerted effort to present data regarding basic science research efforts alongside their translation into clinical practice using combined, integrated multimodal programs of treatment. Progress has been made, but innovatice approaches need to be pursued.



Genomics Proteomics And The Nervous System

Genomics  Proteomics  and the Nervous System PDF
Author: James D Clelland
Publisher: Springer Science & Business Media
ISBN: 9781441971975
Size: 16.93 MB
Format: PDF
Category : Medical
Languages : en
Pages : 592
View: 3502

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Genomics Proteomics And The Nervous System

by James D Clelland, Genomics Proteomics And The Nervous System Books available in PDF, EPUB, Mobi Format. Download Genomics Proteomics And The Nervous System book, This newest volume of Advances in Neurobiology discusses the utilization of genomic and proteomic technologies, to address facets of neurobiology including development and epigenetic regulation, functions in learning and memory, and changes associated with neurological and psychiatric disorders.



Neural Degeneration And Repair

Neural Degeneration and Repair PDF
Author: Hans Werner Müller
Publisher: John Wiley & Sons
ISBN: 3527622470
Size: 77.27 MB
Format: PDF, ePub
Category : Medical
Languages : en
Pages : 249
View: 5075

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Neural Degeneration And Repair

by Hans Werner Müller, Neural Degeneration And Repair Books available in PDF, EPUB, Mobi Format. Download Neural Degeneration And Repair book, With contributions from leading scientists around the world, this is the first book focussing on the analysis of nerve cell damage and repair using genomics, transcriptomics, proteomics and systems biology in order to develop novel therapeutic and diagnostic approaches for neural diseases. Following an introduction into the microarray technology in translational neuroscience, the book goes on to look at the use of '-omics' technologies to analyse molecular changes in traumatic injury, neuron degeneration and regeneration, oxidative stress response, neuropathic pain manifestation etc. The work covers central nervous system as well as peripheral nervous system pathologies. This novel approach makes the book an indispensable companion for neurobiologists, neurologists, cell and molecular biologists, geneticists, and analytical chemists.



The Investigation Of Potential Salivary Protein Biomarkers Of Acute Stress Using Proteomics And Mass Spectrometry

The Investigation of Potential Salivary Protein Biomarkers of Acute Stress Using Proteomics and Mass Spectrometry PDF
Author: Rachel K. Marvin
Publisher:
ISBN:
Size: 73.28 MB
Format: PDF, Mobi
Category : Biochemical markers
Languages : en
Pages : 189
View: 3276

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The Investigation Of Potential Salivary Protein Biomarkers Of Acute Stress Using Proteomics And Mass Spectrometry

by Rachel K. Marvin, The Investigation Of Potential Salivary Protein Biomarkers Of Acute Stress Using Proteomics And Mass Spectrometry Books available in PDF, EPUB, Mobi Format. Download The Investigation Of Potential Salivary Protein Biomarkers Of Acute Stress Using Proteomics And Mass Spectrometry book, The goal of the present research was to elucidate salivary biomarkers of acute stress using proteomic approaches. Acute stress is marked by an increased activity of the sympathetic branch of the autonomic nervous system. Prolonged exposure to acute stress may result in fatigue and chronic stress. Therefore, acute stress has potential social and economic implications in which the performance of workers in high stress occupations (e.g., health care and law enforcement professionals) may be negatively affected. To aide in the monitoring a stress an objective assessment using biomarkers is desirable. Saliva is an optimal body fluid for the discovery and investigation of biomarkers of this physiological state because its secretion is controlled by the autonomic nervous system, and its collection is easy and noninvasive. As people secrete 1-2 L of saliva per day, ample quantities of saliva are typically obtained for qualitative and quantitative analyses of potential biomarkers. In addition, saliva is primarily comprised of water, electrolytes, proteins and hormones whose abundance may be monitored. Consequently, the present analyses involved the examination of the human salivary proteomes at different time points corresponding to non-stressed and acutely stressed states to discover novel protein markers of acute stress. The first project utilized a model system employing the cold pressor test (CPT) to reproducibly induce stress. Participants immersed their non-dominant hand into cold water for a maximum of five minutes, which increases the activity of sympathetic nervous system for the majority of people. Whole saliva was collected before, immediately after and 20 minutes after the CPT. A variety of gel electrophoresis techniques (i.e., SDS-PAGE, 2D-PAGE and 2D-DIGE) was used to assess alterations in the salivary proteome at these three time points. When equal volumes of saliva were analyzed by SDS-PAGE, minor differences in the abundance of some salivary proteins were observed after the CPT. For instance, the amount of cystatins and alpha-amylase is increased immediately after and 20 minutes after the CPT in comparison to the sample obtained prior to the CPT. These differences were also noticed after HPLC was used to separate equal amounts of proteins from the whole saliva samples. Hypothesizing that protein phosphorylation may be influenced by the CPT, tryptic phosphopeptides were isolated from the salivary proteome using immobilized metal affinity chromatography (IMAC). After enrichment, the phosphopeptides were analyzed by nanoHPLC-MALDI-MS/MS, and some differences in the phosphorylation of salivary proteins were observed. Comparing the nanoHPLC chromatograms the peptides eluting at retention times of ~25 and 29.7 minutes had the highest absorbance for the samples collected immediately and 20 minutes after the CPT, indicating that these peptides are present in higher amounts after the stressor. In contrast, the peptide(s) at retention time of ~26.7 minutes had the highest absorbance, and the samples collected after the CPT stressor had a relatively low absorbance. The peptides at these retention times were identified as originating from salivary acidic proline-rich phosphopeptide 1/2. However, the changes in salivary protein abundances and phosphorylation require further characterization before they can be verified as biomarkers of acute stress induced by the CPT. The second project investigated proteins from saliva of medical residents who were placed into a stressed state by performing emergency medicine simulations. Whole saliva was collected from eight medical residents prior to performing the simulation, after the simulation, and the next morning upon waking. Salivary proteins were identified with SDS-PAGE and peptide mass fingerprinting, as well as by nanoHPLC-ESI-MS/MS. Relative quantification of the alpha-amylase, cystatin-type S family, a ~26 kDa band and a low-molecular weight (



Issues In Neuroscience Research And Application 2011 Edition

Issues in Neuroscience Research and Application  2011 Edition PDF
Author:
Publisher: ScholarlyEditions
ISBN: 1464963606
Size: 48.39 MB
Format: PDF, ePub, Mobi
Category : Medical
Languages : en
Pages : 3141
View: 7583

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Issues In Neuroscience Research And Application 2011 Edition

by , Issues In Neuroscience Research And Application 2011 Edition Books available in PDF, EPUB, Mobi Format. Download Issues In Neuroscience Research And Application 2011 Edition book, Issues in Neuroscience Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neuroscience Research and Application. The editors have built Issues in Neuroscience Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuroscience Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Neuroscience Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.



Cns Cancer

CNS Cancer PDF
Author: Erwin G. Van Meir
Publisher: Springer Science & Business Media
ISBN: 9781603275538
Size: 20.74 MB
Format: PDF, ePub, Docs
Category : Medical
Languages : en
Pages : 1284
View: 2060

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Cns Cancer

by Erwin G. Van Meir, Cns Cancer Books available in PDF, EPUB, Mobi Format. Download Cns Cancer book, Cancers of the central nervous system are among the most lethal of human neoplasms. They are recalcitrant to even intensive multimodality therapies that include surgery, radiotherapy, and chemotherapy. Moreover, especially in children, the consequences of these therapies can itself be devastating and involve serious cognitive and developmental disorders. It is small wonder that such cancers have come under the intense scrutiny of each of the subspecialties of clinical care and investigation as well as attracting some of the best basic research scientists. Their joint efforts are gradually peeling away the mysteries surrounding the genesis and progression of these tumors and inroads are being steadily made into understanding why they resist therapies. This makes it an especially opportune time to assemble some of the best investigators in the field to review the ‘‘state of the art’’ in the various arenas that comprise the assault on CNS tumors. The breadth of this effort by the clinical and basic neuro-oncology community is quite simply amazing. To a large extent, it evolves from the knowledge of the human genome and its regulation that has been hard won over the past two decades.



Neural Degeneration And Repair

Neural Degeneration and Repair PDF
Author: Hans Werner Müller
Publisher: John Wiley & Sons
ISBN: 9783527317073
Size: 49.37 MB
Format: PDF, Kindle
Category : Medical
Languages : en
Pages : 249
View: 1457

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Neural Degeneration And Repair

by Hans Werner Müller, Neural Degeneration And Repair Books available in PDF, EPUB, Mobi Format. Download Neural Degeneration And Repair book, With contributions from leading scientists around the world, this is the first book focussing on the analysis of nerve cell damage and repair using genomics, transcriptomics, proteomics and systems biology in order to develop novel therapeutic and diagnostic approaches for neural diseases. Following an introduction into the microarray technology in translational neuroscience, the book goes on to look at the use of '-omics' technologies to analyse molecular changes in traumatic injury, neuron degeneration and regeneration, oxidative stress response, neuropathic pain manifestation etc. The work covers central nervous system as well as peripheral nervous system pathologies. This novel approach makes the book an indispensable companion for neurobiologists, neurologists, cell and molecular biologists, geneticists, and analytical chemists.



Handbook Of Pharmacogenomics And Stratified Medicine

Handbook of Pharmacogenomics and Stratified Medicine PDF
Author: Sandosh Padmanabhan
Publisher: Academic Press
ISBN: 0123868831
Size: 80.92 MB
Format: PDF, ePub, Mobi
Category : Science
Languages : en
Pages : 1118
View: 5492

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Handbook Of Pharmacogenomics And Stratified Medicine

by Sandosh Padmanabhan, Handbook Of Pharmacogenomics And Stratified Medicine Books available in PDF, EPUB, Mobi Format. Download Handbook Of Pharmacogenomics And Stratified Medicine book, Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, proteomics, metabolomics Provides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues Includes chapters on the global implications of pharmacogenomics